Weighing in on genetic testing & research: click here
From evidence-based medicine to genomic medicine: click here
Evidence based medicine in practice: lessons from a Scottish clinical genetics project: click here
The challenge of developing evidence-based genetics health care in practice: click here
Genomic Epidemiology of Complex Disease: The Need for an Electronic Evidence-based Approach to Research Synthesis: click here
Twenty questions in genetic medicine—an assessment of World Wide Web databases for genetics information at the point of care; Genet Med 2008:10(9):659 – 667.
E. Three steps to Genetics/EBM searching
Find the right clinical terms: go to the MeSH database. If terms cannot be mapped against MeSH (Medical Subject Headings) use the nearest equivalent
Combine terms (MeSH or equivalent) using (AND, OR or NOT)
Use filters for PubMed searches, as needed (see bottom of page)
Conduct searches in all of the following databases:
(Differential Diagnosis[MeSH] OR Differential Diagnosis[Text Word] AND Genetics)
Clinical Description
(Natural History OR Mortality OR Phenotype OR Prevalence OR Penetrance AND Genetics)
Management
(therapy[Subheading] OR treatment[Text Word] OR treatment outcome OR investigational therapies AND Genetics)
Genetic Counseling
(Genetic Counseling OR Inheritance pattern AND genetics)
Molecular Genetics
(Medical Genetics OR genotype OR genetics[Subheading] AND genetics)
Genetic Testing
(DNA Mutational Analysis OR Laboratory techniques and procedures OR Genetic Markers OR diagnosis OR testing OR test OR screening OR mutagenicity tests OR genetic techniques OR molecular diagnostic techniques AND genetics)
All
((Diagnosis AND genetics) OR (Differential Diagnosis[MeSH] OR Differential Diagnosis[Text Word] AND genetics) OR (Natural History OR Mortality OR Phenotype OR Prevalence OR Penetrance AND genetics) OR (therapy[Subheading] OR treatment[Text Word] OR treatment outcome OR investigational therapies AND genetics) OR (Genetic Counseling OR Inheritance pattern AND genetics) OR (Medical Genetics OR genotype OR genetics[Subheading] AND genetics) OR (DNA Mutational Analysis OR Laboratory techniques and procedures OR Genetic Markers OR diagnosis OR testing OR test OR screening OR mutagenicity tests OR genetic techniques OR molecular diagnostic techniques AND genetics))
(Note: these genetics searches were developed by staff of GeneReviews: Genetic Disease Online Reviews at GeneTests, University of Washington, Seattle.)
Search tip: choose the service area you require, then click on Go
